منابع مشابه
Humanin is a novel neuroprotective agent against stroke.
BACKGROUND AND PURPOSE Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines the neuroprotective effects of HNG (a potent form of HN) on focal cerebral ischemia/reperfusion injury in mice. METHODS Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reper...
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Neuroprotection aims to prevent neuronal injury, ideally with preservation of function. Many neurological disorders, including ischemic, traumatic, or degenerative insults, share common features of destruction of neurons mediated by similar pathophysiological mechanisms including apoptosis (programmed cell death), increased release of excitotoxic amino acids, (particularly glutamate), intracell...
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An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal dysfunction, Pael-R accumulation, and kainate-induced excitotoxicity. These f...
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Corresponding author: Sungsik Park, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Samduk-2 ga, Joong-gu, Daegu 700-721, Korea. Tel: 82-53-420-5863, Fax: 82-53-426-2760, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativeco...
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Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. T...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2010
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2009.222